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primary topic: Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?
type: AcademicArticle
type: Article
abstract: Isoflavones are a group of (poly)phenols, also defined as phytoestrogens, with chemical structures comparable with estrogen, that exert weak estrogenic effects. These phytochemical compounds have been targeted for their proven antioxidant and protective effects. Recognizing the increasing prevalence of cardiovascular diseases (CVD), there is a growing interest in understanding the potential cardiovascular benefits associated with these phytochemical compounds. Gut microbiota may play a key role in mediating the effects of isoflavones on vascular and endothelial functions, as it is directly implicated in isoflavones metabolism. The findings from randomized clinical trials indicate that isoflavone supplementation may exert putative effects on vascular biomarkers among healthy individuals, but not among patients affected by cardiometabolic disorders. These results might be explained by the enzymatic transformation to which isoflavones are subjected by the gut microbiota, suggesting that a diverse composition of the microbiota may determine the diverse bioavailability of these compounds. Specifically, the conversion of isoflavones in equol—a microbiota-derived metabolite—seems to differ between individuals. Further studies are needed to clarify the intricate molecular mechanisms behind these contrasting results.
date: 2024-02
volume: 17
issue: 2
is part of: Pharmaceuticals
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Texto)
has document: Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Otro)
subject: Biomedicine
subject: Nutrition

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Texto)
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has file: pharmaceuticals-17-00236.pdf
has part: pharmaceuticals-17-00236.pdf

Pharmaceuticals
type: Collection
issn: 14248247

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Federica Martina Di Domenico
type: Person
given name: Federica Martina
family name: Di Domenico

Fabio Galvano
type: Person
given name: Fabio
family name: Galvano

Samuele Laudani
type: Person
given name: Samuele
family name: Laudani

Lucia Gozzo
type: Person
given name: Lucia
family name: Gozzo

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Raquel Martínez Díaz
type: Person
given name: Raquel
family name: Martínez Díaz

Giuseppe Grosso
type: Person
given name: Giuseppe
family name: Grosso

Giovanni Luca Romano
type: Person
given name: Giovanni Luca
family name: Romano

Justyna Godos
type: Person
given name: Justyna
family name: Godos

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Irma Dominguez Azpíroz
type: Person
given name: Irma
family name: Dominguez Azpíroz

Filippo Drago
type: Person
given name: Filippo
family name: Drago

Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Otro)
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Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Otro)
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Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Otro)
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Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Otro)
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Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved? (Otro)
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primary topic: Isoflavones Effects on Vascular and Endothelial Outcomes: How Is the Gut Microbiota Involved?

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es