…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action
type: AcademicArticle
type: Article
abstract: Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota.
date: 2024-07
volume: 16
issue: 15
is part of: Nutrients
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
has document: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)
subject: Biomedicine
subject: Nutrition

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
type: Document
has file: nutrients-16-02471.pdf
has part: nutrients-16-02471.pdf

Nutrients
type: Collection
issn: 20726643

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Giuseppe Grosso
type: Person
given name: Giuseppe
family name: Grosso

Fabio Galvano
type: Person
given name: Fabio
family name: Galvano

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Raquel Martínez Díaz
type: Person
given name: Raquel
family name: Martínez Díaz

Ida Guerrera
type: Person
given name: Ida
family name: Guerrera

Irma Dominguez Azpíroz
type: Person
given name: Irma
family name: Dominguez Azpíroz

Samuele Laudani
type: Person
given name: Samuele
family name: Laudani

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Giovanni Luca Romano
type: Person
given name: Giovanni Luca
family name: Romano

Lucia Gozzo
type: Person
given name: Lucia
family name: Gozzo

Justyna Godos
type: Person
given name: Justyna
family name: Godos

Filippo Drago
type: Person
given name: Filippo
family name: Drago

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)
type: Document
is version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
is volatile version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
is index codes version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
has file: indexcodes.txt
has part: indexcodes.txt

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)
type: Document
is version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
is volatile version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
islightbox thumbnail version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
has file: lightbox.jpg
has part: lightbox.jpg

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)
type: Document
is version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
is volatile version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
ispreview thumbnail version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
has file: preview.jpg
has part: preview.jpg

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)
type: Document
is version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
is volatile version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
ismedium thumbnail version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
has file: medium.jpg
has part: medium.jpg

Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Otro)
type: Document
is version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
is volatile version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
issmall thumbnail version of: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action (Texto)
has file: small.jpg
has part: small.jpg

HTML Summary of #14366 Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action
format: text/html
primary topic: Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action

Biomedicine
type: Concept
preferred label: Biomedicina @es

Nutrition
type: Concept
preferred label: Alimentación @es