%K dengue, outbreak, epidemiology, seasonality, Bangladesh %X Background: The 2023 dengue outbreak has proven that dengue is not only an endemic disease but also an emerging health threat in Bangladesh. Integrated studies on the epidemiology, clinical characteristics, seasonality, and genotype of dengue are limited. This study was conducted to determine recent trends in the molecular epidemiology, clinical features, and seasonality of dengue outbreaks. Methods: We analyzed data from 41 original studies, extracting epidemiological information from all 41 articles, clinical symptoms from 30 articles, and genotypic diversity from 11 articles. The study adhered to the standards of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement and Cochrane Collaboration guidelines. Conclusion: This study provides integrated insights into the molecular epidemiology, clinical features, seasonality, and transmission of dengue in Bangladesh and highlights research gaps for future studies. %J Frontiers in Microbiology %T Evolving epidemiology, clinical features, and genotyping of dengue outbreaks in Bangladesh, 2000–2024: a systematic review %A Nadim Sharif %A Rubayet Rayhan Opu %A Tama Saha %A Abdullah Ibna Masud %A Jannatin Naim %A Khalaf F. Alsharif %A Khalid J. Alzahrani %A Eduardo René Silva Alvarado %A Irene Delgado Noya %A Isabel De la Torre Díez %A Shuvra Kanti Dey %V 15 %L uniromana14950 %D 2024 %R doi:10.3389/fmicb.2024.1481418