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primary topic: Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations

Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations
type: AcademicArticle
type: Article
abstract: Understanding how dietary compounds affect human health is challenged by their molecular complexity and cell-type–specific effects. Conventional multi-cell type (bulk) analyses obscure cellular heterogeneity, while animal and standard in vitro models often fail to replicate human physiology. Single-cell omics technologies—such as single-cell RNA sequencing, as well as single-cell–resolved proteomic and metabolomic approaches—enable high-resolution investigation of nutrient–cell interactions and reveal mechanisms at a single-cell resolution. When combined with advanced human-derived in vitro systems like organoids and organ-on-chip platforms, they support mechanistic studies in physiologically relevant contexts. This review outlines emerging applications of single-cell omics in nutrition research, emphasizing their potential to uncover cell-specific dietary responses, identify nutrient-sensitive pathways, and capture interindividual variability. It also discusses key challenges—including technical limitations, model selection, and institutional biases—and identifies strategic directions to facilitate broader adoption in the field. Collectively, single-cell omics offer a transformative framework to advance human-centric nutrition research.
date: 2025-11
is part of: Critical Reviews in Food Science and Nutrition
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: Nutrition

Critical Reviews in Food Science and Nutrition
type: Collection
issn: 10408398

Giuseppe Grosso
type: Person
given name: Giuseppe
family name: Grosso

José L. Quiles
type: Person
given name: José L.
family name: Quiles

Francesca Giampieri
type: Person
given name: Francesca
family name: Giampieri

Santos Gracia Villar
type: Person
given name: Santos
family name: Gracia Villar

Maurizio Battino
type: Person
given name: Maurizio
family name: Battino

Manuela Cassotta
type: Person
given name: Manuela
family name: Cassotta

Bei Yang
type: Person
given name: Bei
family name: Yang

Zexiu Qi
type: Person
given name: Zexiu
family name: Qi

Jianbo Xiao
type: Person
given name: Jianbo
family name: Xiao

Ge Chen
type: Person
given name: Ge
family name: Chen

Danila Cianciosi
type: Person
given name: Danila
family name: Cianciosi

Yasmany Armas Diaz
type: Person
given name: Yasmany
family name: Armas Diaz

Luis Alonso Dzul López
type: Person
given name: Luis Alonso
family name: Dzul López

HTML Summary of #17867 Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations
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primary topic: Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations

Nutrition
type: Concept
preferred label: Alimentación @es