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Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Icons are the first visual element users encounter when searching for applications in online store. Icons with eye-catching features can make an app stand out in user searches, playing a crucial role in attracting user attention and influencing selection. This increases the likelihood of downloads, which can expand the user base, improve revenue, and enhance engagement, contributing to the application’s overall success. However, the majority of research focused on evaluating appeal of apps through application icons is empirical in nature and may lack comprehensive data analytical approaches. While empirical research holds its significance, it may still be limited by the size of the dataset analyzed and could also be subjective. This proposed research presents a novel data-analytical methodology to analyze a large dataset of application icons from Google Play to determine their influence on downloads. It clusters the icons using three different techniques: -means clustering with two distinct feature vectors and agglomerative clustering, extracting various visual features from the clusters that are strongly correlated with application installs. Subsequently, validation of results has revealed that factors of varied colors, the dominance of white or black colors, text, and exposure in the icons can be linked to downloads. metadata Bilal, Ahmad; Turab Mirza, Hamid; Ahmad, Adnan; Hussain, Ibrar; Raza, Ali; Garay, Helena; Alemany Iturriaga, Josep y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, helena.garay@uneatlantico.es, josep.alemany@uneatlantico.es, SIN ESPECIFICAR (2025) On the correlation between Google Play Store application icons and downloads. The Computer Journal, 68 (10). pp. 1579-1593. ISSN 0010-4620

C

Artículo Materias > Biomedicina
Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Obesity is recognised to be a risk factor for breast cancer since adipose tissue influences the tumour microenvironment. This study aims to investigate the effect of the secretome of 3T3-L1 adipocytes untreated or treated with liquorice root extract (LRE), containing flavonoids, phenolic acids, and saponins on MCF-7 breast cancer cells. By treating adipocytes with LRE, the secretion of certain pro-tumorigenic factors like IGFBP-6, resistin, and VEGF was reduced. MCF-7 cells exposed to conditioned medium from LRE-treated adipocytes exhibited an increase in reactive oxygen species levels, downregulation of the Nrf2 antioxidant pathway, and increased autophagy. Those conditions reduced cell viability, migration, and colony formation. Additionally, there was downregulation of genes associated with oestrogen signalling and tumour-related processes, including CYP19A1 (aromatase), ERα, Her2, and components of the renin–angiotensin system (RAS). These findings suggest that LRE can modulate the adipocyte secretome to influence breast cancer cell behaviour under obesity-related in vitro conditions. metadata Cianciosi, Danila; Armas Diaz, Yasmany; Yang, Bei; Qi, Zexiu; Chen, Ge; Quiles, José L.; Gasparrini, Massimiliano; Cassotta, Manuela; Calderón Iglesias, Rubén; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, jose.quiles@uneatlantico.es, SIN ESPECIFICAR, manucassotta@gmail.com, ruben.calderon@uneatlantico.es, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2026) Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling. International Journal of Food Sciences and Nutrition. pp. 1-24. ISSN 0963-7486

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Understanding how dietary compounds affect human health is challenged by their molecular complexity and cell-type–specific effects. Conventional multi-cell type (bulk) analyses obscure cellular heterogeneity, while animal and standard in vitro models often fail to replicate human physiology. Single-cell omics technologies—such as single-cell RNA sequencing, as well as single-cell–resolved proteomic and metabolomic approaches—enable high-resolution investigation of nutrient–cell interactions and reveal mechanisms at a single-cell resolution. When combined with advanced human-derived in vitro systems like organoids and organ-on-chip platforms, they support mechanistic studies in physiologically relevant contexts. This review outlines emerging applications of single-cell omics in nutrition research, emphasizing their potential to uncover cell-specific dietary responses, identify nutrient-sensitive pathways, and capture interindividual variability. It also discusses key challenges—including technical limitations, model selection, and institutional biases—and identifies strategic directions to facilitate broader adoption in the field. Collectively, single-cell omics offer a transformative framework to advance human-centric nutrition research. metadata Cassotta, Manuela; Armas Diaz, Yasmany; Cianciosi, Danila; Yang, Bei; Qi, Zexiu; Chen, Ge; Gracia Villar, Santos; Dzul López, Luis Alonso; Grosso, Giuseppe; Quiles, José L.; Xiao, Jianbo; Battino, Maurizio y Giampieri, Francesca mail manucassotta@gmail.com, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2025) Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations. Critical Reviews in Food Science and Nutrition. pp. 1-15. ISSN 1040-8398

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Strawberries are commonly consumed berries in the Mediterranean area. The fruits present a high concentration of micronutrients and bioactive compounds that confer a plethora of biological activities, including antioxidant and anti-inflammatory properties. This review discusses and updates the recent results of in vivo studies, in animals and humans, focusing on the impact that strawberry consumption has on many common human diseases, such as obesity, cancer, cardiovascular diseases and metabolic disorders; particular attention has been given to the biological effects and molecular mechanisms involved in the beneficial effects exerted by this berry. Evidence suggests these fruits can contribute to preventing or slowing down the progression of many diseases, even though further research is necessary to confirm their long-term effectiveness, to improve patients’ quality of life or prognosis. metadata Cianciosi, Danila; Armas Diaz, Yasmany; Qi, Zexiu; Yang, Bei; Chen, Ge; Cassotta, Manuela; Gracia Villar, Santos; Dzul López, Luis Alonso; Rivas Garcia, Lorenzo; Forbes Hernandez, Tamara Yuliet; Zhang, Di; Mazzoni, Luca; Mezzetti, Bruno; Battino, Maurizio y Giampieri, Francesca mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, manucassotta@gmail.com, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2025) Strawberry as a health promoter: an evidence-based review. Where are we 10 years later? Food & Function, 16 (14). pp. 5705-5732. ISSN 2042-6496

K

Artículo Materias > Biomedicina
Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Leukemia is a type of blood cell cancer that is in the bone marrow’s blood-forming cells. Two types of Leukemia are acute and chronic; acute enhances fast and chronic growth gradually which are further classified into lymphocytic and myeloid leukemias. This work evaluates a unique deep convolutional neural network (CNN) classifier that improves identification precision by carefully examining concatenated peptide patterns. The study uses leukemia protein expression for experiments supporting two different techniques including independence and applied cross-validation. In addition to CNN, multilayer perceptron (MLP), gated recurrent unit (GRU), and recurrent neural network (RNN) are applied. The experimental results show that the CNN model surpasses competitors with its outstanding predictability in independent and cross-validation testing applied on different features extracted from protein expressions such as amino acid composition (AAC) with a group of AAC (GAAC), tripeptide composition (TPC) with a group of TPC (GTPC), and dipeptide composition (DPC) for calculating its accuracies with their receiver operating characteristic (ROC) curve. In independence testing, a feature expression of AAC and a group of GAAC are applied using MLP and CNN modules, and ROC curves are achieved with overall 100% accuracy for the detection of protein patterns. In cross-validation testing, a feature expression on a group of AAC and GAAC patterns achieved 98.33% accuracy which is the highest for the CNN module. Furthermore, ROC curves show a 0.965% extraordinary result for the GRU module. The findings show that the CNN model is excellent at figuring out leukemia illnesses from protein expressions with higher accuracy. metadata Khawaja, Seher Ansar; Farooq, Muhammad Shoaib; Ishaq, Kashif; Alsubaie, Najah; Karamti, Hanen; Caro Montero, Elizabeth; Silva Alvarado, Eduardo René y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, elizabeth.caro@uneatlantico.es, eduardo.silva@funiber.org, SIN ESPECIFICAR (2024) Prediction of leukemia peptides using convolutional neural network and protein compositions. BMC Cancer, 24 (1). ISSN 1471-2407

R

Artículo Materias > Ingeniería Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés The correct analysis of medical images requires the medical knowledge and expertise of radiologists to understand, clarify, and explain complex patterns and diagnose diseases. After analyzing, radiologists write detailed and well-structured reports that contribute to the precise and timely diagnosis of patients. However, manually writing reports is often expensive and time-consuming, and it is difficult for radiologists to analyze medical images, particularly images with multiple views and perceptions. It is challenging to accurately diagnose diseases, and many methods are proposed to help radiologists, both traditional and deep learning-based. Automatic report generation is widely used to tackle this issue as it streamlines the process and lessens the burden of manual labeling of images. This paper introduces a systematic literature review with a focus on analyses and evaluating existing research on medical report generation. This SLR follows a proper protocol for the planning, reviewing, and reporting of the results. This review recognizes that the most commonly used deep learning models are encoder-decoder frameworks (45 articles), which provide an accuracy of around 92–95%. Transformers-based models (20 articles) are the second most established method and achieve an accuracy of around 91%. The remaining articles explored in this SLR are attention mechanisms (10), RNN-LSTM (10), Large language models (LLM-10), and graph-based methods (4) with promising results. However, these methods also face certain limitations such as overfitting, risk of bias, and high data dependency that impact their performance. The review not only highlights the strengths and challenges of these methods but also suggests ways to handle them in the future to increase the accuracy and timely generation of medical reports. The goal of this review is to direct radiologists toward methods that lessen their workload and provide precise medical diagnoses. metadata Rehman, Marwareed; Shafi, Imran; Ahmad, Jamil; Osorio García, Carlos Manuel; Pascual Barrera, Alina Eugenia y Ashraf, Imran mail SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, carlos.osorio@uneatlantico.es, alina.pascual@unini.edu.mx, SIN ESPECIFICAR (2024) Advancement in medical report generation: current practices, challenges, and future directions. Medical & Biological Engineering & Computing. ISSN 0140-0118

S

Artículo Materias > Alimentación Universidad Europea del Atlántico > Investigación > Producción Científica
Universidad Internacional Iberoamericana México > Investigación > Producción Científica
Universidad Internacional Iberoamericana Puerto Rico > Investigación > Producción Científica
Universidad Internacional do Cuanza > Investigación > Producción Científica
Universidad de La Romana > Investigación > Producción Científica Cerrado Inglés Food security is a universal need worldwide. This study explored the relationship between food security and adherence to the Mediterranean diet in the context of the DELICIOUS project. A survey involving 2,011 parents of children and adolescents aged 6–17 years was conducted. Adherence to the Mediterranean diet was assessed through the KIDMED score. Information regarding the ease of accessing Mediterranean foods, economic allowance, employment and residence was collected. Logistic regressions analyses were performed to test the associations. Individuals living in rural areas and reporting difficulty in obtaining all studied foods were less likely to follow the Mediterranean diet. Higher adherence was associated with a household monthly income higher than €4000. No associations with family status and no differences across countries were found. The progressive shift away from the Mediterranean diet may depend not only on cultural preferences for unhealthier, industrial alternatives but also on family budgets and food accessibility. metadata Scazzina, Francesca; Rosi, Alice; Giampieri, Francesca; Poveda-Loor, Carlos; Abdelkarim, Osama; Aly, Mohamed; Frias-Toral, Evelyn; Pons, Juancho; Vázquez-Araújo, Laura; Sumalla Cano, Sandra; Elío Pascual, Iñaki; Monasta, Lorenzo; Paladino, Nadia; Mata, Ana; Chacón, Adrián; Busó, Pablo y Grosso, Giuseppe mail SIN ESPECIFICAR, SIN ESPECIFICAR, francesca.giampieri@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, sandra.sumalla@uneatlantico.es, inaki.elio@uneatlantico.es, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR, SIN ESPECIFICAR (2025) Socio-economic status, food security and adherence to the Mediterranean diet in five Mediterranean countries: the DELICIOUS project. International Journal of Food Sciences and Nutrition, 76 (8). pp. 869-877. ISSN 0963-7486

Este listado fue generado el Fri May 29 23:46:41 2026 UTC.

Liquorice alters adipocyte–breast cancer cell crosstalk by modulating oxidative stress and suppressing aromatase and renin–angiotensin signalling

Obesity is recognised to be a risk factor for breast cancer since adipose tissue influences the tumour microenvironment. This study aims to investigate the effect of the secretome of 3T3-L1 adipocytes untreated or treated with liquorice root extract (LRE), containing flavonoids, phenolic acids, and saponins on MCF-7 breast cancer cells. By treating adipocytes with LRE, the secretion of certain pro-tumorigenic factors like IGFBP-6, resistin, and VEGF was reduced. MCF-7 cells exposed to conditioned medium from LRE-treated adipocytes exhibited an increase in reactive oxygen species levels, downregulation of the Nrf2 antioxidant pathway, and increased autophagy. Those conditions reduced cell viability, migration, and colony formation. Additionally, there was downregulation of genes associated with oestrogen signalling and tumour-related processes, including CYP19A1 (aromatase), ERα, Her2, and components of the renin–angiotensin system (RAS). These findings suggest that LRE can modulate the adipocyte secretome to influence breast cancer cell behaviour under obesity-related in vitro conditions.

Producción Científica

Danila Cianciosi mail , Yasmany Armas Diaz mail , Bei Yang mail , Zexiu Qi mail , Ge Chen mail , José L. Quiles mail jose.quiles@uneatlantico.es, Massimiliano Gasparrini mail , Manuela Cassotta mail manucassotta@gmail.com, Rubén Calderón Iglesias mail ruben.calderon@uneatlantico.es, Maurizio Battino mail maurizio.battino@uneatlantico.es, Francesca Giampieri mail francesca.giampieri@uneatlantico.es,

Cianciosi

open

An Integrated Machine Learning and Genomic Framework for Precise Detection of Gastric Cancer

This study presents a novel integrative approach for the analysis of high-dimensional gene expression data, leveraging the complementary strengths of unsupervised clustering and supervised classification. Using K-means clustering, the dataset is stratified into three distinct clusters, revealing intrinsic biological patterns and relationships. The resulting cluster assignments are subsequently employed as pseudo-labels to train machine learning models, including support vector machines, random forest, and a stacking ensemble classifier. To validate and enhance the robustness of clustering, complementary methodologies such as hierarchical clustering and DBSCAN are employed, with results visualized through PCA-driven dimensionality reduction. The high predictive accuracy achieved by the classifiers underscores the separability and reliability of the identified clusters. Furthermore, feature importance analysis highlighted key genetic determinants within each cluster, offering actionable insights into potential biomarkers and critical genomic features. This framework bridges the gap between exploratory unsupervised learning and predictive supervised modeling, providing a scalable and interpretable methodology for analyzing complex genomic datasets. Its applicability extends to biomarker discovery, patient stratification, and other precision medicine applications, emphasizing its utility in advancing genomic research and clinical practice.

Producción Científica

Eshmal Iman mail , Sohail Jabbar mail , Shabana Ramzan mail , Ali Raza mail , Farwa Raoof mail , Stefanía Carvajal-Altamiranda mail stefania.carvajal@uneatlantico.es, Vivian Lipari mail vivian.lipari@uneatlantico.es, Imran Ashraf mail ,

Iman

open

A novel approach for disease and pests detection in potato production system based on deep learning

Vulnerability of potato crops to diseases and pest infestation can affect its quality and lead to significant yield losses. Timely detection of such diseases can help take effective decisions. For this purpose, a deep learning-based object detection framework is designed in this study to identify and classify major potato diseases and pests under real-world field conditions. A total of 2,688 field images were collected from two research farms in Punjab, Pakistan, across multiple growth stages in various seasonal conditions. Excluding 285 symptoms-free images from the earliest collection led to 2,403 images which were annotated into four biotic-stress classes: blight disease (n = 630), leaf spot disease (n = 370), leafroll virus (viral symptom complex; n = 888), and Colorado potato beetle (larvae/adults; n = 515), indicating class imbalance. Several state-of-the-art models were used including YOLOv8 variants (n/s/m), YOLOv7, YOLOv5, and Faster R-CNN, and the results are discussed in relation to recent potato disease classification studies involving cropped leaf images. Stratified splitting (70% training, 20% validation, 10% testing) was applied to preserve class distribution across all subsets. YOLOv8-medium achieve the best performance with mean average precision (mAP)@0.5 of 98% on the held-out test images. Results for stable 5-fold cross-validation show a mean mAP@0.5 of 97.8%, which offers a balance between accuracy and inference time. Model robustness was evaluated using 5-fold cross-validation and repeated training with different random seeds, showing a low variance of ±0.4% mAP. Results demonstrate promising outcomes under the real-world field conditions, while, broader cross-region and cross-season validation is intended for the future.

Producción Científica

Ahmed Abbas mail , Saif Ur Rehman mail , Khalid Mahmood mail , Santos Gracia Villar mail santos.gracia@uneatlantico.es, Luis Alonso Dzul López mail luis.dzul@uneatlantico.es, Aseel Smerat mail , Imran Ashraf mail ,

Abbas

open

An attention-based deep learning model for early detection of polyphagous shot hole borer infestations in plants

The Polyphagous Shot Hole Borer (PSHB) is a highly invasive beetle that has been spreading like an epidemic across agricultural and forestry landscapes in recent years. Its rapid and destructive spread has turned it into a major global threat, causing widespread damage that continues to grow with time. Countries like South Africa, the United States, and Australia have implemented extensive measures to control the spread of PSHB, including the establishment of specialized agricultural support centers for early detection. However, there is still a strong need to make PSHB detection more accessible, allowing even non-experts to easily identify infections at an early stage. Artificial Intelligence (AI) has shown great promise in plant disease detection, but a major challenge in the case of PSHB was the lack of a suitable dataset for training AI models. In the proposed work, we first created a dedicated dataset by collecting images of trees infected with PSHB. We applied a range of preprocessing techniques to refine the dataset and prepare it for AI applications. Building on this, we developed a novel AI-based method, where we trained a deep learning model using a multi-convolutional layer network combined with a Fourier transformation layer. Additionally, an attention mechanism and advanced feature extraction techniques were incorporated to further boost model performance. As a result, the proposed approach achieved an impressive top accuracy of 92.3% in detecting PSHB infections, showing the potential of AI to offer a simple, efficient, and highly accurate solution for early disease detection.

Producción Científica

Rabbiya Younas mail , Hafiz Muhammad Raza ur Rehman mail , Gyu Sang Choi mail , Ángel Gabriel Kuc Castilla mail angel.kuc@uneatlantico.es, Carlos Eduardo Uc Ríos mail carlos.uc@unini.edu.mx, Imran Ashraf mail ,

Younas

open

Correction: Enhancing fault detection in new energy vehicles via novel ensemble approach

In the original version of this Article, Umair Shahid was incorrectly listed as a corresponding author. The correct corresponding authors for this Article are Imran Ashraf and Kashif Munir. Correspondence and request for materials should be addressed to ashrafimran@live.com and kashif.munir@kfueit.edu.pk.

Producción Científica

Iqra Akhtar mail , Mahnoor Nabeel mail , Umair Shahid mail , Kashif Munir mail , Ali Raza mail , Irene Delgado Noya mail irene.delgado@uneatlantico.es, Santos Gracia Villar mail santos.gracia@uneatlantico.es, Imran Ashraf mail ,

Akhtar

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